Somerville, Massachusetts-February 11, 2020-Hint Issues Scientific right now launched SPion ™ -a revolutionary know-how that allows the world’s most delicate and versatile distant evaluation with mass spectrometry. Till now, a scarcity of correct instrumentation for environment friendly ion switch from a remotely positioned pattern to the mass spectrometer made delicate in situ evaluation for such a pattern almost inconceivable. SPion™ overcomes this main roadblock by redefining the front-end structure of a mass spectrometer and remodeling it right into a easy light-weight handheld probe. SPion™ permits scientists to carry the accuracy and specificity of a mass spectrometer to their pattern in native state, and expertise unprecedented sensitivity in distant evaluation. This enables for, amongst different purposes, in vivo or dwelling pattern molecular profiling. This shall be revolutionary for well being and organic sciences together with most cancers surgical procedure as a result of the tissue or pattern would not must be altered or handled to sensitively measure the biomarkers.

“SPion™ addresses one of many vital challenges that had remained unsolved for a lot of a long time within the discipline of mass spectrometry: the aptitude to effectively switch ions over comparatively lengthy distances, much like how photons are contained and guided by means of optical fibers,” mentioned Mazdak Taghioskoui, Ph.D., Hint Issues Scientific’s CEO and the inventor of the know-how. “Mass spectrometry is without doubt one of the strongest strategies for capturing molecular data and is an influence device for precision and personalised drugs. The capabilities that SPion™ brings to the desk extends the usage of mass spectrometry to much more purposes, importantly, point-of-care in vivo direct tissue evaluation. Our aim is to show a mass spec right into a medical gadget -a device that may present extremely correct tissue biopsy leads to real-time within the working room.”

The in vivo pattern evaluation functionality is a recreation changer as a result of it permits observing the biology and chemistry of dwelling tissue with out disruption. Sometimes, samples should be eliminated for evaluation, and within the course of, an excessive amount of time and accuracy is sacrificed. Along with producing extra related information through in vivo evaluation, SPion™ addresses many issues related to ex vivo strategies, equivalent to tedious pattern preparation, cross-contamination, bias developments, and instability of analytes. With SPion™, it’s now doable to supply molecular data immediately from a dwelling tissue with the identical sensitivity of a normal mass spectrometer.

Within the first ever implementation of this know-how, Hint Issues is working with Nathalie Agar, Ph.D., Division of Neurosurgery at Brigham and Ladies’s Hospital and Affiliate Professor of Neurosurgery at Harvard Medical Faculty to display the know-how in most cancers surgical procedure. “Over the previous decade, the main target of my analysis has been on the potential of mass spectrometry in supporting and guiding surgical decision-making, with the aim of totally integrating mass spectrometry within the scientific setting,” mentioned Professor Agar, the director of the Surgical Molecular Imaging Laboratory on the Brigham. “We’re completely happy to have the chance to work on validating, optimizing, and implementing this new thrilling know-how.”


Hint Issues is planning to current the outcomes on the 68th ASMS Convention on Mass Spectrometry and Allied Matters (ASMS) 2020 in Houston, TX. Be taught extra about SPion™ at


Within the preliminary Choose Launch, SPion™ shall be made obtainable to a small group of main scientists world-wide with essentially the most demanding urgency. Be taught extra concerning the Choose Launch at

About Hint Issues Scientific

Hint Issues is a know-how startup centered on growing the subsequent technology of mass spectrometry applied sciences for a wide range of demanding purposes. Hint Issues applied sciences embody revolutionary mass spectrometry {hardware}, strategies, and purposes to resolve essentially the most demanding mass spectrometry evaluation wants in varied industries.

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SPion™ is neither provided, marketed, nor meant to be used as a “medical gadget,” as outlined by the U.S. Meals and Drug Administration’s rules, or different counterpart overseas entities. SPion™ is just not meant to be used within the analysis of illness or different situations, or within the treatment, mitigation, therapy, or prevention of illness, in man or animals. SPion™ is meant and marketed solely to be used in analysis settings.

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